Current theories suggest that the brain is the sole source of mental illness. However, affective disorders, and major depressive disorder (MDD) in particular, may be better conceptualized as brain-body disorders that involve peripheral systems as well. This perspective emphasizes the embodied, multifaceted physiology of well-being, and suggests that afferent signals from the body may contribute to cognitive and emotional states. In this review, we focus on evidence from preclinical and clinical studies suggesting that afferent thermosensory signals contribute to well-being and (...) depression. Although thermoregulatory systems have traditionally been conceptualized as serving primarily homeostatic functions, increasing evidence suggests neural pathways responsible for regulating body temperature may be linked more closely with emotional states than previously recognized, an affective warmth hypothesis. Human studies indicate that increasing physical warmth activates brain circuits associated with cognitive and affective functions, promotes interpersonal warmth and prosocial behavior, and has antidepressant effects. Consistent with these effects, preclinical studies in rodents demonstrate that physical warmth activates brain serotonergic neurons implicated in antidepressant-like effects. Together, these studies suggest that (1) thermosensory pathways interact with brain systems that control affective function, (2) these pathways are dysregulated in affective disorders, and (3) activating warm thermosensory pathways promotes a sense of well-being and has therapeutic potential in the treatment of affective disorders. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hamann and the Philosophy of David Hume CHARLES W. SWAIN There have been many and various interpretations of Hume's philosophy; no one, so far as I know, has ever viewed him as a romantic. On the other hand, Johann Georg Hamann, "the wizard of the North," has gained his modicum of notoriety mainly through his influence on German romanticism, plus the fact that Kierkegaard mentions him approvingly, and (...) even quotes him in the Philosophical Fragments. Hume has been regarded as a sceptic, an empiricist, a naturalist and a positivist; Hamann is usually regarded as an irrationalist and proto-existentialist. 1 These two thinkers were certainly very different; yet Hamann had a profound appreciation for the philsophy of Hume. I want to suggest in this paper that a study of the use to which Hamann put Hume's philosophy may raise some difficulties for the prevailing view of Hamann's thought, and may also open up a somewhat different perspective on Hume's thought. Hamann found himself in rebellion against the spirit of his age. He saw in Hume an ally in his struggle against the over-confident rationalism of the Enlightenment. As an apologist, Hamann set himself the task of "smoking out the stylish spirit of the century by means of doubt." e He set about this task in a series of strange apologetic works, written in a deliberately mystifying, sometimes shocking style. His anti-rationalism made him a hero to the later romantics, and a mystery to his friends and readersmamong them his fellow citizen, Immanuel Kant. Beginning as a university student, Hamann had become a disciple of the Enlightenment, seeking his place in the brave new world of the early eighteenth century. He tried a career as a tutor, along with many a young man seeking an independent and comfortable life. Eventually he accepted a vaguely defined position with the mercantile firm of Berens in Riga, operated by the family of his college friend Johann Cristoph Berens. Hamann undertook a "secret mission" for the Berens firm which brought him to London in 1758 where, lonely and disheartened, he underwent a personal crisis which changed the direction of his life and resulted in his career as a man of letters and an apologist for Christianity against the Enlightenment. Having been a devotee for over a decade, Hamann felt that he knew the spirit of the Enlightenment. His opposition, however, baffling it may have appeared to his contemporaries, was not intended as obscurantism. He had his 1Hamann has been much more in vogue on the continent than in the English-speaking world. According to Martin Sells, Theologische Aspekte zur gegenw~irtigen Hamann-deutung (GSttingen: Vandenhoek und Ruprecht, 1957),p. 105,der Magus has been claimed as a spiritual ancestor by virtually every European intellectual movement of the last 150 yearst Philologische Einf~illeund Zwei]el, Iqadler iii, 41. [343] 344 HISTORY OF PHILOSOPHY "reasons," and a study of his use of Hume's philosophy will help to clarify this aspect of his thought. Hamann's acquaintance with the philosophy of Hume dates from his university days, where he was probably introduced to the world of English letters by his fondly remembered teacher, Heinrich Rappolt. Rappolt was a Wolffian, but not at all interested in the attempt to reconcile Wolffianism with pietistic Christianity --in contrast to his more renowned colleague, Martin Knutzen, Kant's teacher. Rappolt had traveled and studied in England, and apparently delighted in opening these new intellectual vistas to his students, s Hamann thus became familiar with Hume's political and economic writings, as well as his philosophical works. Already in 1756, during his Holmeister period, he had worked through an edition of Hume's works which contained various economic and political essays as well as the First Enquiry. 4 Hume's works were among the books which he bought (but perhaps never read) during his stay in London. In 1759, when he published his first apologetic work, Socratische Denku~rdigkeiten, he was (in his own words) "full of Hume." 5 He cites Hume throughout his literary career, and acknowledges his intellectual debt to Hume both publicly and privately. One of his last undertakings was a translation... (shrink)

Kegley's primary intent is to show that neo-realism ignores factors that influence international actors, and that a theory is needed that expands the notion of self-interest to include the moral sphere.

Charles Mills makes visible in the world of mainstream philosophy some of the crucial issues of the black experience.

In few cases among modern religious ethicists are the contemporary issues concerning the problem of norms and of criteria more intriguingly brought to the fore than in the ethics of Martin Buber.

The ongoing pursuit of tacit knowledge Content Type Journal Article Pages 1-5 DOI 10.1007/s11016-010-9500-6 Authors Charles W. Smith, Department of Sociology, Queens College, CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

The Enlightenment was the age in which the world became modern, challenging tradition in favor of reason, freedom, and critical inquiry. While many aspects of the Enlightenment have been rigorously scrutinized—its origins and motivations, its principal characters and defining features, its legacy and modern relevance—the geographical dimensions of the era have until now largely been ignored. Placing the Enlightenment contends that the Age of Reason was not only a period of pioneering geographical investigation but also an age with spatial dimensions (...) to its content and concerns. Investigating the role space and location played in the creation and reception of Enlightenment ideas, Charles W. J. Withers draws from the fields of art, science, history, geography, politics, and religion to explore the legacies of Enlightenment national identity, navigation, discovery, and knowledge. Ultimately, geography is revealed to be the source of much of the raw material from which philosophers fashioned theories of the human condition. Lavishly illustrated and engagingly written, Placing the Enlightenment will interest Enlightenment specialists from across the disciplines as well as any scholar curious about the role geography has played in the making of the modern world. (shrink)

This previously-unpublished essay by the late Charles W. Mills (1951–2021) seeks to demonstrate the racially-structured character of the universe created by J. R. R. Tolkien in The Hobbit and The Lord of the Rings. Written long before the popular film series, the essay critically examines Tolkien's novels and comments on the nature of fictional creation. Mills argues that Tolkien designs a racial hierarchy in the novels that recapitulates the central racist myth of European thought.

In lieu of an abstract, here is a brief excerpt of the content:Place and the "Spatial Turn" in Geography and in HistoryCharles W. J. WithersI. IntroductionA few years ago, British Telecom ran a newspaper advertisement in the British press about the benefits—and consequences—of advances in communications technology. Featuring a remote settlement in the north-west Highlands of Scotland, and with the clear implication that such "out-of-the-way places" were now connected to the wider world (as if they had not been before), the (...) advert proclaimed "Geography is History." What the advert signalled to as the "end" of geography in the sense of the social gradients associated with space and distance is what is known, variously, as "time-space convergence" and "time-space distanciation."1 The terms embrace not just the "collapse" of geographical space given technical advances (in travel time and in communications—consequences of what Castells calls "the information age" and "the network society"2), but also the idea that the modern world has become [End Page 637] more homogenized. One place is now much the same as another. Further, given the likelihood of such technical and cultural changes continuing into the future, geographical distinctiveness, evident in the particularity of place, would be a thing of the past: geography would indeed be history. There is, of course, much evidence to the contrary: that, in the face of "globalisation," questions of locality, sense of place and of identity in place matter now more than ever. Even, then, as Francis Fukuyama cautioned against the "death" of liberal democratic politics as The End of History,3 geography—that is, geography understood as questions to do with place, and questions to do with where you are in the world as part of questions about how you are and who you are in the world—has had considerably heightened significance and for some places and people more than others.4These notions of place—as a particular location, and the character or sense of place—are only part of the meanings associated with place in geographical and in historical work. Like space, its regular epistemic dancing partner in geographical ubiquity and metaphysical imprecision, place is a widespread yet complex term. What follows is historiographical in focus and, of necessity, partial in range. I offer a historiographical survey of the term place, principally but not alone within recent work in geography. In more detail, and with reference to one of the strong senses in which place is used, namely that of locale, "the local," or localness, I trace here the connections between place, space, and the idea of the local as evident in recent work in history and in geography, especially within the history and the geography of science. Particular attention is paid in this context to the distinctive features of what we may think of as the "spatial turn" in the history of science by looking at the idea of place and space in recent work in Enlightenment studies. My argument is three-fold. Notions of place and space, much debated by geographers, have been as central a concern for intellectual historians and historians of science as for philosophers and others, but they have been differently expressed. There is, I shall argue, value in looking at these different views in order to understand that whilst place is a commonplace term it is not agreed upon: working with imprecision has been both opportunity and restriction. In relation to work within the history of science and in Enlightenment studies, consideration of the so-called "spatial turn," of place [End Page 638] as social practice and of placing as a process in accounting for the uneven movement of ideas over space and time may help provide some precision and strengthen connections between geography and history.II. Place (In Geography): A Partial HistoriographyPlace is one of the most fundamental concepts in human geography. It is also one of the most problematic.5 Place, or small-scale regional space, features as a subdivision within the Classical tripartite division of cosmography (the earth in relation to other planetary bodies), geography (the earth as a whole) and chorography (parts of the earth or regional geography). So, too, does the distinction between chorography and chronology as... (shrink)

Foundations of the theory of signs.--Signs, language, and behavior.--Five semiotical studies.

Abstract:Therapeutic misconception (TM)—when clinical research participants fail to adequately grasp the difference between participating in a clinical trial and receiving ordinary clinical care—has long been recognized as a significant problem in consent to clinical trials. We suggest that TM does not primarily reflect inadequate disclosure or participants’ incompetence. Instead, TM arises from divergent primary cognitive frames. The researchers’ frame places the clinical trial in the context of scientific designs for assessing intervention efficacy. In contrast, most participants have a cognitive frame (...) that is personal and focused primarily on their medical problems. To illustrate this, we draw on interview material from both clinical researchers and participants in clinical trials. We suggest that reducing TM requires encouraging subjects to adjust their frame, not just add information to their existing frame. What is necessary is ascientific reframingof participation in a clinical trial. (shrink)

This essay tries to develop a “black radical Kantianism”—that is, a Kantianism informed by the black experience in modernity. After looking briefly at socialist and feminist appropriations of Kant, I argue that an analogous black radical appropriation should draw on the distinctive social ontology and view of the state associated with the black radical tradition. In ethics, this would mean working with a (color-conscious rather than colorblind) social ontology of white persons and black sub-persons and then asking what respect for (...) oneself and others would require under those circumstances. In political philosophy, it would mean framing the state as a Rassenstaat (a racial state) and then asking what measures of corrective justice would be necessary to bring about the ideal Rechtsstaat. (shrink)

‘Racial justice’ is a term widely used in everyday discourse, but little explored in philosophy. In this essay, I look at racial justice as a concept, trying to bring out its complexities, and urging a greater engagement by mainstream political philosophers with the issues that it raises. After comparing it to other varieties of group justice and injustice, I periodize racial injustice, relate it to European expansionism and argue that a modified Rawlsianism relying on a different version of the thought (...) experiment could come up with suitable principles of corrective racial justice. (shrink)

For several decades, Dr. Morris has worked primarily with twoproblems: the development of a general theory of signs, and thedevelopment of a general theory of value. He approached both problemsin terms of George Mead's theory of action or behavior. This bookbrings together these two lines of development. For several decades, Dr. Morris has worked primarily with two problems: the development of a general theory of signs, and the development of a general theory of value. He approached both problems in terms (...) of George Mead's theory of action or behavior. This book brings together these two lines of development. In many languages there is a term like the English "meaning" which has two poles: that which something signifies and the value or significance of what is signified. The nature of signification and significance, as well as their relations within human behavior, is the subject matter of this book. This book is addressed to philosophers and to students of the behavioral sciences, but it will also appeal to anyone seriously interested in the study of human communication. (shrink)

White supremacy is the unnamed political system that has made the modern world what it is today. You will not find this term in introductory, or even advanced, texts in political theory. A standard undergraduate philosophy course will start off with plato and Aristotle, perhaps say something about Augustine, Aquinas, and Machiavelli, move on to Hobbes, Locke, Mill, and Marx, and then wind up with Rawls and Nozick. It will introduce you to notions of aristocracy, democracy, absolutism, liberalism, representative government, (...) socialism, welfare capitalism, andlibertarianism. But though it covers more than two thousand years of Western political thought and runs the ostensible gamut of political systems, there will be no mention of the basic political system that has shaped the world for the past several hundred years. And this omission is not accidental. Rather, it reflects the fact that standard textbooks and courses have for the most part been written and designed by whites, who take their racial privilege so much for granted that they do not even see it as political, as a form of domination. Ironically, the most important political system of recent global history-the system of domination by which white people have historically ruled over and, in certain important ways, continue to rule over nonwhite people-is not seen as a political system at all. It is just taken for granted; it is the background against which other systems, which we are to see as political are highlighted. This book is an attempt to redirect your vision, to make you see what, in a sense, has been there all along. (shrink)

The new National Institutes of Health (NIH) Policy on the Use of a Single Institutional Review Board (sIRB) for Multi-Site Research was adopted primarily to simplify and speed the review of complex multisite clinical trials. However, speeding review requires overcoming a number of obstacles. Perhaps the most substantial obstacle is the time and effort needed to develop reliance agreements among the participating sites. We conducted 102 semistructured interviews with sIRB personnel, including directors, chairs, reviewers, and staff, from 20 IRBs that (...) acted as sIRBs for multisite research, including 6 commercial/independent sIRBs, and 10 university-based academic and 4 federal sIRBs. Almost without exception, the interviewees agreed that reliance agreements were complex, difficult to develop, and time-consuming. A major problem for relying sites was that different agreements specified different responsibilities for the relying sites. Attitudes differed about whether these problems will be resolved as IRB staff and managers become more experienced with sIRBs. However it is clear that the process of developing reliance agreements must be simplified. Federal assistance in standardizing at least some sections of reliance agreements might reduce the difficulties involved. (shrink)

After a brief summary of the 17 essays in Sally Haslanger’s (2012) collection, Resisting Reality: Social Construction and Social Critique, I raise questions in two areas, the defense of constructionism and the definition of gender and race in terms of social oppression. I cite Robin Andreasen’s and Philip Kitcher’s essays arguing (in different ways) that races are both biologically real and socially constructed, and also Joshua Glasgow’s claim that constructionist arguments ultimately fail. I then cite Jennifer Saul’s critique that “oppression” (...) definitions of gender and race run into problematic counterexamples, and add some other points arising from the different histories of gender and racial categories and realities. As someone sympathetic to constructionism myself, my aim is not a critique of Haslanger but rather an inquiry as to how she thinks (we) constructionists should answer such challenges. (shrink)

Drawing on the legacy of prominent pragmatic philosophers and political economists—C. S. Peirce, William James, John Dewey, Thorstein Veblen, and John R. Commons—Charles W. Anderson creatively brings pragmatism and liberalism together, striving to temper the excesses of both and to fashion a broader vision of the proper domain of political reason.

The “Occupy Wall Street!” movement has stimulated a long listing of other candidates for radical “occupation.” In this paper, I suggest the occupation of liberalism itself. I argue for a constructive engagement of radicals with liberalism in order to retrieve it for a radical egalitarian agenda. My premise is that the foundational values of liberalism have a radical potential that has not historically been realized, given the way the dominant varieties of liberalism have developed. Ten reasons standardly given as to (...) why such a retrieval cannot be carried out are examined and shown to be fallacious. (shrink)